Cristiano Ronaldo has tested positive for coronavirus.
The Juventus forward is feeling well and hasn’t been suffering with symptoms, but is now self-isolating and will play no part in Portugal’s clash with Sweden.
The rest of the Portugal team have returned negative tests and are available for selection.
Portugal’s Football Federation said: “Cristiano Ronaldo was released from the work of the National Team after a positive test for COVID-19, so he will not face Sweden.
“The Portuguese international is doing well, without symptoms, and in isolation.
“Following the positive case, the remaining players underwent new tests this Tuesday morning, all with a negative result, and are available to Fernando Santos for training this afternoon, in the City of Football.
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“The game, counting for the qualification phase of the League of Nations, is scheduled for Wednesday, at 19:45, in Alvalade.”
Portugal take on Sweden in the Nations League on Wednesday night.
Ronaldo, 35, played the full 90 minutes of Portugal’s goalless draw with France in Paris on Sunday, having also featured against Spain in Lisbon last Thursday.
Portugal boss Fernando Santos said of the draw with France: “It was a very even game; the players were too cautious. I don’t know if there was too much respect from both sides, but the game looked like that. It wasn’t very fast, but it was balanced.
Portugal go into the match top of Group C having won two of their opening fixtures and drawing the other against Les Bleus.
Sweden have lost all three of their opening matches and are rock bottom without a point.