Chelsea travel to King Power Stadium to battle Leicester City as defending Champions Manchester City to visit Saint James Park to take on Newcastle United in the Emirate FA Cup quarter-final.
The Blues have been handed tough away tie with both Premier League meetings have ended in draws, with Antonio Rudiger scoring twice in a four-goal thriller at the beginning of February.
Holders Manchester City beat Sheffield Wednesday 1-0 on Wednesday night thanks to a goal from Sergio Aguero and will face a Newcastle United side who were runners-up in 1998 and 1999.
Sheffield United and Arsenal – two teams competing for the Premier League top four – now take battle in another competition, the Blades hosting the Gunners in an impossible-to-pick cup tie.
The last quarter-final tie won’t be confirmed until Thursday night.
Manchester United take on Wayne Rooney’s Derby County at Pride Park with a trip to Norwich City the reward for the winner.
The Premier League’s bottom side came from behind to beat Tottenham Hotspur on penalties with Tim Krul proving to be the hero as he saved from Troy Parrott and Gedson Fernandes.
FA Cup quarter-final draw in full: