Barcelona make the trip to Italy to face Napoli in the first leg of their Champions League last-16 tie having put together a three-match winning streak in La Liga.
The home side have also enjoyed a strong recent run, registering three victories in all competitions to boost their chances in Serie A and the Coppa Italia.
Napoli will be sweating on the fitness of commanding centre-back Kalidou Koulibaly, who missed this weekend’s fixture against Brescia as the Senegalese star is currently suffering from a hamstring issue that occurred against Parma last month.
Kevin Malcuit remains a long-term injury concern with cruciate ligament damage but Fernando Llorente is expected to recover from flu for the game.
Barcelona will be without Luis Suarez, Ousmane Dembele and Jordi Alba for this tie as the three are suffering from serious injuries and will not be available for selection.
New signing Martin Braithwaite is not eligible to play.
Head to Head
Tuesday night’s fixture will represent the first time that these two clubs have faced each other in a competitive match.
Napoli have been in excellent form – winning six of their previous seven matches. This run has included wins against Juventus and Inter.
Gattuso’s side have showcased a more efficient method of football and while it isn’t the most attractive football, it has been effective.
For Barcelona, Lionel Messi ended his relative goal drought by scoring four goals in their 5-0 win against Eibar with the Champions League returning this Tuesday and El Clasico next weekend, the pressure is on for Setien to deliver results.
Barcelona Predicted Lineups (4-3-3): Ter Stegen; Semedo, Piqué, Lenglet, Firpo; De Jong, Busquets, Arthur; Messi, Griezmann, Vidal.
Napoli Predicted Lineups (4-3-3): Meret; Di Lorenzo, Manolas, Maksimovic, Mário Rui; Fabián, Demme, Zielinski; Callejón, Mertens, Insigne.
Prediction: Napoli 1-2 Barcelona